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Exatecan mesylate

CAS號	169869-90-3
規格	1mg5mg	純度	98%
貨號	HY-13631A	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	1mg5mg
純度	98%
貨號	HY-13631A
貨期	3天
品牌	Medchemexpress
庫存	---
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參考價：￥5115.00 元/1mg

立即詢盤

貨號	品牌	純度	規格	參考價	貨期
HY-13631A	Medchemexpress	98%	1mg5mg	￥5115.00元/1mg	3天

產品詳情

詳細信息(中文)：
Exatecan(DX-8951)甲磺酸鹽是拓撲異構酶I抑制劑喜樹堿的合成類似物，增加了其水溶性和抗腫瘤活性，降低了毒性。

詳細信息(英文)：
產品描述：Exatecan (Mesylate)Exatecan Mesylate (DX-8951) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself._x000D_ IC50 value:_x000D_ Target: topoisomerase I_x000D_ Exatecan was given as i.v. infusion over 30 min at a dose of 0.5mg/m2 every day for five consecutive days, repeated every 21 days. Seventy-four percentage of cycles could be given without dose or schedule modification. The main toxicity was haematotoxicity with grade 3/4 neutropenia in 49%, grade 3/4 thrombocytopenia in 23%, and grade 3/4 anaemia in 15% of patients, respectively [1]. The most common drug-related toxicity was neutropenia. Non-hematologic toxicities were mostly mild to moderate; the most common were nausea, vomiting and anorexia. Plasma concentrations of DX-8951 (the anhydrous form of DX-8951f) were well described using a linear 2-compartment PK model. All concentrations and dose events were simult 公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區子公司和亞洲區總代理，營銷網點遍及全球20多個國家地區。MCE經過多年努力已成為全球生物活性小分子領域的一流供應商，產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業定制合成服務。 MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被全球近萬名客戶廣泛使用并發表大量文章、專利； MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；數千種產品在上海有充足備貨，24-48小時內送達客戶；大量產品提供免費試用裝；已為全球多個知名企業、院校構建各種定制型化合物庫。產品鏈接：www.medchemexpress.cn/exatecan-mesylate.html