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CAS號	1452458-86-4
規格	1g/包，10g/包	純度	≥98%
貨號	WTM-06-00	貨期	需咨詢
品牌	唯特醫藥科技	庫存	20g
規格	1g/包，10g/包
純度	≥98%
貨號	WTM-06-00
貨期	---
品牌	唯特醫藥科技
庫存	20g
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥15000.00 元/克

立即詢盤

貨號	品牌	純度	規格	參考價	貨期
WTM-06-00	唯特醫藥科技	≥98%	1g/包，10g/包	￥15000.00元/克	---

產品詳情

詳細信息(中文)：
Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.

詳細信息(英文)：
Nacubactam is a Phase 3-ready beta-lactamase inhibitor which works through multiple mechanisms of action, inhibiting a number of beta-lactamase enzymes as well as certain bacterial cell wall enzymes, lending the candidate a broad spectrum of activity when used in combination with beta-lactam antibiotics. In non-clinical studies, nacubactam-meropenem was shown to have potent antimicrobial activity against complicated urinary tract and severe respiratory tract infections, including those caused by meropenem-resistant strains, and against infections caused by CRE. In previously reported Phase 1 clinical studies, it was demonstrated that intravenous nacubactam was well tolerated among healthy volunteers when administered alone or in combination with meropenem. In these studies, nacubactam had no effect on ECG or vital signs parameters, and no trends in laboratory tests were observed. Pharmacokinetic studies in renal impaired patients and in cUTI patients have also been completed.